Acquired multiple secondary <i>BRCA2</i> mutations upon PARPi resistance in a metastatic pancreatic cancer patient harboring a <i>BRCA2</i> germline mutation.
Haitao Tao, Sisi Liu, Di Huang, Han Xiao, Xue Wu, Yang Shao, Yi Hu
Abstract
mutations to restore the integrity of DNA repair and confer drug resistance, which may contribute to the unimproved overall survival in pancreatic cancer patients.
Topics & Concepts
OlaparibMedicinePancreatic cancerPARP inhibitorGermline mutationCancer researchPTENKRASGermlineMetastasisCancerOncologyBRCA2 ProteinPALB2Internal medicineMutationBiologyGeneticsGenePoly ADP ribose polymeraseColorectal cancerPI3K/AKT/mTOR pathwayApoptosisPolymerasePARP inhibition in cancer therapyBRCA gene mutations in cancerDNA Repair Mechanisms