Functional injectable hydrogel with spatiotemporal sequential release for recruitment of endogenous stem cells and <i>in situ</i> cartilage regeneration
Wenling Dai, Qingli Liu, Shikui Li, Yongli Gao, Cong Feng, Likun Guo, Yumei Xiao, Hai Lin, Yujiang Fan, Xingdong Zhang
Abstract
results indicated that the Col-Apt@KGN MPs hydrogel effectively promoted the recruitment of endogenous MSCs in a rabbit full-thickness cartilage defect model; furthermore, the Col-Apt@KGN MPs hydrogel enhanced the secretion of cartilage specific extracellular matrix and achieved the reconstruction of subchondral bone. This study demonstrates that the Col-Apt@KGN MPs hydrogel possesses great potential in recruitment of endogenous stem cells and cartilage tissue regeneration.
Topics & Concepts
Regeneration (biology)In situCartilageEndogenySelf-healing hydrogelsMaterials scienceBiomedical engineeringStem cellCell biologyAnatomyChemistryBiologyMedicinePolymer chemistryBiochemistryOrganic chemistryOsteoarthritis Treatment and MechanismsPeriodontal Regeneration and TreatmentsSilk-based biomaterials and applications