Strain-dependent variations in replication of European clade 2.3.4.4b influenza A(H5N1) viruses in bovine cells and thermal inactivation in semi-skimmed or whole milk
Diana I. Palme, Juliane Lang, Dajana Helke, Maryna Kuryshko, Elsayed M. Abdelwhab
Abstract
We investigated the thermostability of four European avian influenza A(H5N1) viruses in whole and semi-skimmed milk and their replication in bovine kidney and lung cells amid the current influenza A(H5N1) dairy cattle outbreak in the United States. Results showed strain-dependent differences in thermal inactivation, particularly in whole milk, and variable replication efficacy in lung cells. These findings support assessing the inactivation of European H5N1 viruses in milk and their replication in bovine cells, aiding biosafety protocols and public health measures.
Topics & Concepts
Influenza A virus subtype H5N1Skimmed milkVirologyStrain (injury)BiologyReplication (statistics)VirusFood scienceAnatomyInfluenza Virus Research StudiesAnimal Disease Management and EpidemiologyViral gastroenteritis research and epidemiology