Electrochemical detection of acetaminophen and caffeine using Ag nanoparticles doped metal-organic framework (ZIF-67) composites
Juan Wang, Feilong Yin, Wenjing Tang, Nini Zhang, Liang Li, Shengbiao Zheng, Jing Tang, Jiahao Guo
Abstract
The combination of metal organic framework (MOFs) with metal nanoparticles has great prospects for improving the electrochemical property of sensors. In this paper, silver (Ag) nanoparticles doping Co-based zeolitic imidazolate framework (ZIF-67) composites (Ag-ZIF-67) were prepared by ultrasonic treatment of ZIF-67 and reduction of metal precursor (AgNO3) in ZIF-67 material. Ag-ZIF-67 nanosheet material was obtained and characterized by transmission electron microscopy and electrochemical impedance spectroscopy. Due to the synergistic effect of high porosity and large specific surface area of ZIF-67, as well as the high electrical conductivity and prominent catalytic activity of Ag nanoparticles, Ag-ZIF-67 modified glassy carbon electrode showed excellent electrocatalytic activity for the detection of acetaminophen (AP) and caffeine (CAFF), including wide linear range (0.1-70.0 μM) for AP and (0.5-300.0 μM) for CAFF, high anti-interference ability. Additionally, the prepared Ag-ZIF-67 sensor also exhibited excellent selectivity for two compounds detection and prospective results in pharmaceutical formulations samples.