Disulfiram/copper triggers cGAS-STING innate immunity pathway via ROS-induced DNA damage that potentiates antitumor response to PD-1 checkpoint blockade
Mengmeng Yuan, Liang Shi, Yan Liu, Xiang Ke, Yan Zhang, Ye Zhou, Jianling Wang, Meiju Ji, Peng Hou
Abstract
cytotoxic lymphocytes and natural killer (NK) cells, and potentiated the therapeutic efficacy of PD-1 checkpoint blockade in murine tumor models. Overall, our findings provide a rationale underlying the anti-cancer and immunomodulatory function of DSF/Cu and highlight the potential of repurposing DSF to improve responses to ICBs in cancer patients.
Topics & Concepts
DisulfiramBlockadeInnate immune systemDNA damageStingImmune checkpointImmunityCancer researchChemistryPharmacologyDNAMedicineImmunologyImmune systemBiochemistryReceptorEngineeringAerospace engineeringinterferon and immune responsesInflammasome and immune disordersCancer Immunotherapy and Biomarkers