Emerging roles for G‐quadruplexes in proteostasis
Bryan B. Guzmán, Ahyun Son, Theodore J. Litberg, Zijue Huang, Daniel Domínguez, Scott Horowitz
Abstract
How nucleic acids interact with proteins, and how they affect protein folding, aggregation, and misfolding is a still-evolving area of research. Considerable effort is now focusing on a particular structure of RNA and DNA, G-quadruplexes, and their role in protein homeostasis and disease. In this state-of-the-art review, we track recent reports on how G-quadruplexes influence protein aggregation, proteolysis, phase separation, and protein misfolding diseases, and pose currently unanswered questions in the advance of this scientific field.
Topics & Concepts
ProteostasisProtein foldingNucleic acidProtein aggregationComputational biologyRNABiologyChemistryCell biologyBiochemistryGeneDNA and Nucleic Acid ChemistryRNA Interference and Gene DeliveryRNA and protein synthesis mechanisms