Biological activity of lyophilized chitosan scaffolds with inclusion of chitosan and zinc oxide nanoparticles
Jorge Eliecer Viloria Angarita, Daniel Insuasty, Juan David Rodríguez M., Jorge Iván Castro, Carlos Humberto Valencia-Llano, Paula A. Zapata, Johannes Delgado‐Ospina, Diana Paola Navia Porras, Alberto Ricardo Albis Arrieta, Carlos David Grande‐Tovar
Abstract
, evaluation confirmed the biocompatibility of the functionalized scaffolds, where F2 showed accelerated resorption attributed to the NPs-ZnO. At the same time, F3 exhibited controlled degradation with NPs-CS acting as initiation points for degradation. On the other hand, F4 combined NPs-CS and NPs-ZnO, resulting in progressive degradation, reduced inflammation, and an organized extracellular matrix. All the results presented expand the boundaries in tissue engineering and regenerative medicine by highlighting the crucial role of nanoparticles in optimizing scaffold properties.