Novel 1,5-diaryl pyrazole-3-carboxamides as selective COX-2/sEH inhibitors with analgesic, anti-inflammatory, and lower cardiotoxicity effects
Omnia M. Hendawy, Hesham A. M. Gomaa, Sami I. Alzarea, Mutariah S. Alshammari, Fatma A. Mohamed, Yaser A. Mostafa, Ahmed H. Abdelazeem, Mostafa Abdelrahman, Laurent Trembleau, Bahaa G. M. Youssif
Topics & Concepts
ChemistryCelecoxibAnti-inflammatoryPharmacologyAnalgesicPyrazoleIC50In vivoCardiotoxicityStereochemistryIn vitroBiochemistryToxicityMedicineOrganic chemistryBiologyBiotechnologyEicosanoids and Hypertension PharmacologySynthesis and biological activitySynthesis and Biological Evaluation