Intestinal Organoids Generated from Human Pluripotent Stem Cells
Satoru Tsuruta, Hajime Uchida, Hidenori Akutsu
Abstract
by PSCs, contain not only epithelium but also mesenchymal tissue and partially recapitulate intestinal functions. Such intestinal organoids have begun to be applied in disease models and drug development and have contributed to a detailed analysis of molecular interactions and findings in the synergistic development of biomedicine for human digestive organs. In this review, we describe gastrointestinal organoid technology derived from PSCs and consider its potential applications.
Topics & Concepts
OrganoidInduced pluripotent stem cellEmbryonic stem cellStem cellBiologyCell biologyGerm layerRegenerative medicineMesenchymal stem cellGastrointestinal epitheliumIntestinal epitheliumAdult stem cellEpitheliumGeneticsGenePluripotent Stem Cells ResearchCancer Cells and Metastasis3D Printing in Biomedical Research