Neutrophil extracellular traps mediate m<sup>6</sup>A modification and regulates sepsis-associated acute lung injury by activating ferroptosis in alveolar epithelial cells
Hao Zhang, Jinlong Liu, Yilu Zhou, Mengdi Qu, Yanghanzhao Wang, Kefang Guo, Ruling Shen, Zhirong Sun, Juan P. Cata, Shuofei Yang, Wankun Chen, Changhong Miao
Abstract
, we elucidated and confirmed the critical role of ferroptosis in NETs-induced ALI. These findings support a role for NETs-induced METTL3 modification and the subsequent induction of ferroptosis in the pathogenesis of sepsis-associated ALI.
Topics & Concepts
Neutrophil extracellular trapsSepsisPathogenesisExtracellularLungDownregulation and upregulationIn vitroImmunologyInflammationIn vivoMedicineCell biologyBiologyGeneInternal medicineBiochemistryBiotechnologyNeutrophil, Myeloperoxidase and Oxidative MechanismsRNA modifications and cancerImmune cells in cancer