Angiotensin II acts through Rac1 to upregulate pendrin: role of NADPH oxidase
Truyen D. Pham, Jill W. Verlander, Chao Chen, Vladimír Pech, Hailey I. Kim, Young Hee Kim, I. David Weiner, Ginger L. Milne, Roy Zent, Fabian Bock, Dennis Brown, Amity F. Eaton, Susan M. Wall
Abstract
This study defines a new signaling mechanism by which angiotensin II modulates oxidative stress and blood pressure.
Topics & Concepts
PendrinAngiotensin IIChemistryEndocrinologyInternal medicineNADPH oxidaseRenin–angiotensin systemApical membraneRAC1Cell biologyBiologyBiochemistrySignal transductionReceptorReactive oxygen speciesMedicineTransporterMembraneGeneBlood pressureNeutrophil, Myeloperoxidase and Oxidative MechanismsIon channel regulation and functionNitric Oxide and Endothelin Effects