RNA-binding protein MEX3A controls G1/S transition via regulating the RB/E2F pathway in clear cell renal cell carcinoma
Yuntan Qiu, Meng Meng, Chuanzhen Cao, Jingyuan Zhang, Cheng Xu, Yongxin Huang, Haotian Cao, Yun Li, Duanqing Tian, Yongsheng Huang, Li Peng, Kaishun Hu, Yin Zhang, Jian‐You Liao, Jiehua He, Xiaochun Wang, Daning Lu, Lehang Lin, Xingang Bi, Dong Yin
Abstract
3' untranslated region, promoting its mRNA degradation. This leads to decreased levels of CDKN2B and an uncontrolled cell cycle in clear cell renal cell carcinoma, which was confirmed by rescue experiments. Our findings revealed that MEX3A acts as a post-transcriptional regulator of abnormal cell-cycle progression in clear cell renal cell carcinoma.
Topics & Concepts
E2FRenal cell carcinomaCell biologyTransition (genetics)RNACellRNA-binding proteinChemistryCancer researchCell cycleBiologyMedicineInternal medicineBiochemistryGeneRenal cell carcinoma treatmentRenal and related cancersRNA modifications and cancer