Pharmacological inhibition of Kv1.3 channel impairs TLR3/4 activation and type I IFN response and confers protection against Listeria monocytogenes infection
Xin Zhang, Xiulin Lin, Hui Luo, Yuanxing Zhi, Xin Yi, Xiaoyan Wu, Wen-Di Duan, Ying Cao, Jianxin Pang, Shuwen Liu, Pingzheng Zhou
Topics & Concepts
TLR3Proinflammatory cytokineTLR4MAPK/ERK pathwayEffluxInterferonBiologyImmune systemTLR2Innate immune systemToll-like receptorSignal transductionChemistryCell biologyInflammationImmunologyBiochemistryImmune Response and InflammationImmune Cell Function and Interactioninterferon and immune responses