GRP78-targeted and doxorubicin-loaded nanodroplets combined with ultrasound: a potential novel theranostics for castration-resistant prostate cancer
Yading Zhao, Dandan Shi, Mengmeng Shang, Xiao Sun, Lu Guo, Dong Meng, Xinxin Liu, Xiaoying Zhou, Jie Li
Abstract
investigations showed that SP94-DOX-NDs combined with ultrasound could specifically deliver DOX into 22RV1 cells and thereby demonstrated a stronger anticancer effect than DOX-NDs and DOX. Thus, SP94-DOX-NDs may provide an efficient approach for the real-time imaging of tumors and triggered, accurate drug delivery to tumors.
Topics & Concepts
DoxorubicinIn vivoProstate cancerBiocompatibilityDrug deliveryCancer researchUltrasoundTargeted drug deliveryCancerIn vitroMaterials scienceBiomedical engineeringMedicineChemistryNanotechnologyChemotherapyBiologyBiochemistryInternal medicineRadiologyBiotechnologyMetallurgyUltrasound and Hyperthermia ApplicationsNanoplatforms for cancer theranosticsPhotoacoustic and Ultrasonic Imaging