Hsa_circ_0001756 promotes ovarian cancer progression through regulating IGF2BP2-mediated RAB5A expression and the EGFR/MAPK signaling pathway
Jing Ji, Chen Li, Jinfeng Wang, Lei Wang, Huifang Huang, Ying Li, Jing Fang
Abstract
. In conclusion, hsa_circ_0001756 knockdown inhibits OC cell proliferation, invasion, and EMT, and reduces xenograft tumor growth by suppressing IGF2BP2-mediated RAB5A expression and blocking the EGFR/MAPK signaling pathway.
Topics & Concepts
Gene knockdownBiologyTransfectionCell growthDownregulation and upregulationSmall interfering RNACell cultureMolecular biologyCancer researchBlotGeneBiochemistryGeneticsCircular RNAs in diseasesMicroRNA in disease regulationCancer-related molecular mechanisms research