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Covid-19 Vaccine Effectiveness and the Test-Negative Design

Natalie E. Dean, Joseph W. Hogan, Mireille E. Schnitzer

2021New England Journal of Medicine196 citationsDOIOpen Access PDF

Abstract

Observational studies are emerging as fundamental sources of information about vaccine effectiveness outside the controlled environment of randomized trials, and they are being used to generate evi...

Topics & Concepts

Observational studyCoronavirus disease 2019 (COVID-19)Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)Randomized controlled trial2019-20 coronavirus outbreakTest (biology)MedicineVirologyInternal medicineBiologyOutbreakInfectious disease (medical specialty)PaleontologyDiseaseSARS-CoV-2 and COVID-19 ResearchVaccine Coverage and HesitancyCOVID-19 Clinical Research Studies
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