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Quadriceps motor unit properties following ACL reconstruction are associated with corticospinal excitability and motor cortex activations

David A. Sherman, Jonathan P. Beausejour, Moein Koohestani, Matt S. Stock, Grant E. Norte

2025Journal of Applied Physiology10 citationsDOIOpen Access PDF

Abstract

Individuals with anterior cruciate ligament reconstruction (ACLR) exhibited earlier recruitment of larger MUs with lower firing rates at both absolute and mass-normalized recruitment thresholds in their involved limb when compared with contralateral and control limbs. Individuals with ACLR had lower corticospinal excitability and lower contralateral hemisphere motor cortex activations, which were weakly associated with lower firing rates as larger motor units were recruited. Reduced excitatory cortical drive may contribute to quadriceps motor unit impairments and persistent quadriceps weakness after ACLR.

Topics & Concepts

Transcranial magnetic stimulationVastus medialisPrimary motor cortexMotor cortexCorticospinal tractNeuroscienceElectromyographyMotor unitPyramidal tractsSensory systemMedicinePhysical medicine and rehabilitationElectrophysiologyPsychologyStimulationMagnetic resonance imagingRadiologyDiffusion MRIMuscle activation and electromyography studiesTranscranial Magnetic Stimulation StudiesMotor Control and Adaptation
Quadriceps motor unit properties following ACL reconstruction are associated with corticospinal excitability and motor cortex activations | Litcius