Transdermal delivery of allopurinol to acute hyperuricemic mice <i>via</i> polymer microneedles for the regulation of serum uric acid levels
Rui Wang, Han Wang, Guohua Jiang, Yanfang Sun, Tianqi Liu, Lei Nie, Amin Shavandi, Khaydar E. Yunusov, Uladzislau E. Aharodnikau, Sergey O. Solomevich
Abstract
study demonstrated that the AP-loaded MN system can effectively reduce the SUA levels as oral administration with lower side effects, which will be conducive to reducing the adverse reactions and improving the bioavailability of AP. This MN-mediated strategy can facilitate transcutaneous hyperuricemia treatment and provide a new alternative for the exploration of clinical treatment of hyperuricemia and improvement of patient compliance.
Topics & Concepts
TransdermalAllopurinolUric acidChemistryPharmacologyBiochemistryMedicineInternal medicineAdvancements in Transdermal Drug DeliveryToxin Mechanisms and ImmunotoxinsDermatology and Skin Diseases