Mammalian Target of Rapamycin (mTOR) Signaling at the Crossroad of Muscle Fiber Fate in Sarcopenia
Giuseppe Sirago, Anna Picca, Riccardo Calvani, Hélio José Coelho‐Júnior, Emanuele Marzetti
Abstract
The mammalian target of rapamycin (mTOR) is a major regulator of skeletal myocyte viability. The signaling pathways triggered by mTOR vary according to the type of endogenous and exogenous factors (e.g., redox balance, nutrient availability, physical activity) as well as organismal age. Here, we provide an overview of mTOR signaling in skeletal muscle, with a special focus on the role played by mTOR in the development of sarcopenia. Intervention strategies targeting mTOR in sarcopenia (e.g., supplementation of plant extracts, hormones, inorganic ions, calorie restriction, and exercise) have also been discussed.
Topics & Concepts
PI3K/AKT/mTOR pathwaySarcopeniaRegulatorSkeletal muscleCalorie restrictionCell biologyRPTORBiologySignal transductionEndocrinologyBiochemistryGeneMuscle Physiology and DisordersMuscle metabolism and nutritionMetabolism, Diabetes, and Cancer