l-Citrulline Supports Vascular and Muscular Benefits of Exercise Training in Older Adults
Arturo Figueroa, Salvador J. Jaime, Masahiko Morita, Joaquin U. Gonzales, Christophe Moinard
Abstract
Age-associated reduction in endothelial nitric oxide (NO) synthesis contributes to the development of cardiovascular diseases and sarcopenia. L-Citrulline is a precursor of NO with the ability to improve vascular function and muscle protein synthesis. We hypothesize that vascular and muscular benefits associated with oral L-citrulline supplementation might be augmented by concomitant supplementation with exercise training in older adults.
Topics & Concepts
SarcopeniaCitrullineNitric oxideMedicineInternal medicinePhysical therapyArginineEndocrinologyBiochemistryBiologyAmino acidCardiovascular and exercise physiologyMuscle metabolism and nutritionCardiovascular Health and Disease Prevention