Palladium-Catalyzed Allenamide Carbopalladation/Allylation with Active Methine Compounds
Xiaoyi Zhu, Ruibo Li, Hequan Yao, Aijun Lin
Abstract
A palladium-catalyzed allenamide carbopalladation/allylation with active methine compounds has been developed. Various indoles and isoquinolinones bearing a quaternary carbon center were achieved with good efficiency, a broad substrate scope and good functional group tolerance. This reaction underwent cascade oxidative addition, carbopalladation, and allylic alkylation, and two new C-C bonds were formed in one pot.
Topics & Concepts
ChemistryPalladiumCatalysisAllylic rearrangementTsuji–Trost reactionFunctional groupSubstrate (aquarium)AlkylationCombinatorial chemistryMedicinal chemistryOrganic chemistryGeologyOceanographyPolymerCatalytic C–H Functionalization MethodsCatalytic Cross-Coupling ReactionsCatalytic Alkyne Reactions