Effect of conditioning and physiological hyperthermia on canine skeletal muscle mitochondrial oxygen consumption
Michael S. Davis, Montana Barrett
Abstract
Athletic conditioning is expected to increase exercise capacity through improved function of cardiopulmonary and musculoskeletal tissues. Our finding of decreased calculated efficiency of skeletal muscle mitochondria in one of the premier mammalian athletes suggests that this mandate for improved function may take the form of sacrificing capacity for maximal oxidative phosphorylation to minimize exercise-induced muscle damage caused by mitochondrial oxidative stress.
Topics & Concepts
Skeletal muscleOxidative phosphorylationOxidative stressMitochondrionHyperthermiaConditioningOxygenMedicineInternal medicineEndocrinologyChemistryBiologyCell biologyBiochemistryMathematicsOrganic chemistryStatisticsCardiovascular and exercise physiologyExercise and Physiological ResponsesCardiovascular Effects of Exercise