Regioselective <i>ortho</i> halogenation of <i>N</i> -aryl amides and ureas <i>via</i> oxidative halodeboronation: harnessing boron reactivity for efficient C–halogen bond installation
Ganesh Shinde, Ganesh S. Ghotekar, Francoise M. Amombo Noa, Lars Öhrström, Per‐Ola Norrby, Henrik Sundén
Abstract
We report the discovery of an ortho regioselective oxidative halodeboronation of N -aryl amides and ureas with wide-ranging applications in pharmaceuticals, materials science, and synthetic organic chemistry.
Topics & Concepts
RegioselectivityChemistryArylHalogenationReactivity (psychology)HalogenBorylationCombinatorial chemistryElectrophileBoronAmideOxidative phosphorylationOrganic chemistryCatalysisMedicineAlternative medicinePathologyAlkylBiochemistryCatalytic C–H Functionalization MethodsOrganoboron and organosilicon chemistryCatalytic Cross-Coupling Reactions