Immunohistochemical PSMA expression patterns of primary prostate cancer tissue are associated with the detection rate of biochemical recurrence with <sup>68</sup>Ga-PSMA-11-PET
Daniela A. Ferraro, Jan H. Rüschoff, Urs J. Muehlematter, Benedikt Kranzbühler, Julian Müller, Michael Messerli, Lars Husmann, Thomas Hermanns, Daniel Eberli, Niels J. Rupp, Irene A. Burger
Abstract
Prostate-specific membrane antigen (PSMA) targeted PET has a high detection rate for biochemical recurrence (BCR) of prostate cancer (PCa). Nevertheless, even at high prostate-specific antigen (PSA) levels (> 3 ng/ml), a relevant number of PSMA-PET scans are negative, mainly due to PSMA-negative PCa. Our objective was to investigate whether PSMA-expression patterns of the primary tumour on immunohistochemistry (IHC) are associated with PSMA-PET detection rate of recurrent PCa.
Topics & Concepts
Biochemical recurrenceImmunohistochemistryProstate cancerProstateCancer detectionPathologyTissue microarrayMedicineCancerCancer researchOncologyInternal medicineProstatectomyProstate Cancer Treatment and ResearchProstate Cancer Diagnosis and TreatmentCancer, Lipids, and Metabolism