Effect of gastric microbiota on quadruple <i>Helicobacter pylori</i> eradication therapy containing bismuth
Zhanyue Niu, Sizhu Li, Yanyan Shi, Yan Xue
Abstract
BACKGROUND: . AIM: eradication treatment. METHODS: infection underwent gastroscopy and received treatment for eradication. The prescription included esomeprazole 20 mg bid, Livzon Dele 220 mg bid, amoxicillin 1000 mg bid, and clarithromycin 500 mg bid for 14 d. Patients who did not respond to treatment and failed eradication were compared with those who achieved eradication by 1:2 propensity matching. High-throughput sequencing of the gastric mucosal microbiota was performed, and the results were evaluated by alpha diversity analysis, beta diversity analysis, species correlation analysis, and metabolic pathway correlation analysis. RESULTS: in the successful group compared with the failure group. CONCLUSION: .