β‐Alkylation through Dehydrogenative Coupling of Primary Alcohols and Secondary Alcohols Catalyzed by Thioether‐Functionalized N‐Heterocyclic Carbene Ruthenium Complexes
Victoria Mechrouk, A. Maisse-Francois, Stéphane Bellemin‐Laponnaz, Thierry Achard
Abstract
Abstract A catalytic system for the direct β‐alkylation of secondary alcohol with primary alcohol has been investigated. In this work, a series of cationic Ru(II)(η 6 ‐ p ‐cymene) complexes with thioether‐functionalized N‐heterocyclic carbene ligands (imidazole‐based 1 a – l and benzimidazole‐based 2 a – e ) have been successfully synthesized and evaluated as catalysts. This investigation shows that modifications in the ligand moiety (thioether group and/or NHC core) have a strong effect on both selectivity and reactivity. Imidazole‐based complex 1 c , with only 1 mol % of catalyst loading, displayed the best catalytic activity as well as the highest selectivity for the β‐alcohol up to 98 : 2 for this tandem borrowing hydrogen/aldol methodology. Applied to a wide range of substrates, β‐alkylated secondary alcohols have been obtained in moderate yields, but generally with complete conversion and very high selectivity.