Engineered lipid nanoparticles enable therapeutic gene silencing of GTSE1 for the treatment of liver fibrosis
Michaela Jeong, Sumin Shin, Gyeongseok Lee, Yeji Lee, Seo Bhin Park, Jisoo Kang, Young‐Sun Lee, Wonhyo Seo, Hyukjin Lee
Topics & Concepts
Gene silencingDownregulation and upregulationFibrosisCancer researchHepatocyteExtracellular matrixRNA interferenceLiver functionHepatocyte nuclear factor 4microRNACell biologyChemistryMedicineBiologyGenePathologyRNAIn vitroTranscription factorInternal medicineBiochemistryNuclear receptorRNA Interference and Gene DeliveryAnimal Virus Infections StudiesLiver physiology and pathology