Remdesivir and SARS-CoV-2: Structural requirements at both nsp12 RdRp and nsp14 Exonuclease active-sites
Ashleigh Shannon, Thi-Tuyet-Nhung Le, Barbara Selisko, Cécilia Eydoux, Karine Alvarez, Jean‐Claude Guillemot, Étienne Decroly, Olve B. Peersen, François Ferrón, Bruno Canard
Topics & Concepts
ExonucleaseBiologyProofreadingRNA-dependent RNA polymerasePolymeraseVirologyRNACoronavirusRNA polymeraseGeneticsNucleoside triphosphateComputational biologyNucleotideDNAGeneCoronavirus disease 2019 (COVID-19)MedicineInfectious disease (medical specialty)PathologyDiseaseSARS-CoV-2 and COVID-19 ResearchViral Infections and Immunology ResearchCRISPR and Genetic Engineering