From off-to on-target: New BRAF-inhibitor-template-derived compounds selectively targeting mitogen activated protein kinase kinase 4 (MKK4)
Philip Klövekorn, Bent Pfaffenrot, Michael Juchum, Roland Selig, Wolfgang Albrecht, Lars Zender, Stefan Laufer
Topics & Concepts
ChemistryKinaseProtein kinase AMitogen-activated protein kinaseSelectivityRegulatorCell biologyBiochemistryBiologyGeneCatalysisMelanoma and MAPK PathwaysComputational Drug Discovery MethodsSynthesis and biological activity