Visualization of the cysteine level during Golgi stress using a novel Golgi-targeting highly specific fluorescent probe
Xue Zhang, Caiyun Liu, Yanan Chen, Xinyu Cai, Wenlong Sheng, Hanchuang Zhu, Pan Jia, Zilu Li, Shengyun Huang, Baocun Zhu
Abstract
A novel Golgi-targeting Cys-specific fluorescent probe (Gol-Cys) was synthesized. Probe Gol-Cys is not only sufficiently sensitive to native Cys in living cells and zebrafish, but also can be used for monitoring the Cys level during Golgi stress.
Topics & Concepts
Golgi apparatusFluorescenceCysteineChemistryBiophysicsVisualizationCell biologyNanotechnologyBiochemistryComputational biologyBiologyMaterials scienceComputer scienceCellEnzymePhysicsData miningOpticsSulfur Compounds in BiologyMolecular Sensors and Ion DetectionBiomedical Research and Pathophysiology