Solvent mixtures in pharmaceutical development: Maximizing the API solubility and avoiding phase separation
Stefanie Dohrn, Christian Luebbert, Kristin Lehmkemper, Samuel O. Kyeremateng, Matthias Degenhardt, Gabriele Sadowski
Topics & Concepts
ChemistrySolubilitySolventSolvationTetrahydrofuranAcetoneDichloromethaneMethanolHildebrand solubility parameterOrganic chemistryMethyl acetatePhase (matter)SolvophobicChromatographyCrystallization and Solubility StudiesChemical and Physical Properties in Aqueous SolutionsAnalytical Chemistry and Chromatography