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Mitochondrial DNA release mediated by TFAM deficiency promotes copper-induced mitochondrial innate immune response via cGAS-STING signalling in chicken hepatocytes

Quanwei Li, Shaofeng Wang, Pan Guo, Yuanhong Feng, Wenlan Yu, Hui Zhang, Jianying Guo, Ying Li, Lianmei Hu, Jiaqiang Pan, Jianzhao Liao, Zhaoxin Tang

2023The Science of The Total Environment21 citationsDOI

Topics & Concepts

IRF3Innate immune systemTFAMStimulator of interferon genesBiologyCell biologyTANK-binding kinase 1InterferonMitochondrial DNAMitochondrionPhosphorylationImmune systemImmunologyProtein kinase ABiochemistryMitochondrial biogenesisGeneMitogen-activated protein kinase kinaseinterferon and immune responsesViral Infections and VectorsImmune Response and Inflammation
Mitochondrial DNA release mediated by TFAM deficiency promotes copper-induced mitochondrial innate immune response via cGAS-STING signalling in chicken hepatocytes | Litcius