Discovery and characterisation of an amidine-containing ribosomally-synthesised peptide that is widely distributed in nature
Alicia H. Russell, Natalia M. Vior, Edward S. Hems, Rodney Lacret, Andrew W. Truman
Abstract
) was characterised, leading to the discovery of streptamidine, a novel amidine-containing RiPP. This new BGC family highlights the breadth of unexplored natural products with structurally rare features, even in model organisms.
Topics & Concepts
ActinobacteriaGenomeStreptomycesComputational biologyNatural productBiologyAmidineGeneBiochemistryBacteriaChemistryGeneticsStereochemistry16S ribosomal RNAMicrobial Natural Products and BiosynthesisRNA and protein synthesis mechanismsGenomics and Phylogenetic Studies