Thienylpiperidine Donor NIR Xanthene-Based Dye for Photoacoustic Imaging
Chathuranga S. L. Rathnamalala, Nicholas W. Pino, Bailey S. Herring, Mattea Hooper, Steven R. Gwaltney, Jefferson Chan, Colleen N. Scott
Abstract
Few xanthene-based near-infrared (NIR) photoacoustic (PA) dyes with absorbance >800 nm exist. As accessibility to these dyes requires long and tedious synthetic steps, we designed a NIR dye (XanthCR-880) with thienylpiperidine donors and a xanthene acceptor that is accessible in 3–4 synthetic steps. The dye boasts a strong PA signal at 880 nm with good biological compatibility and photostability, yields multiplexed imaging with an aza-BODIPY reference dye, and is detected at a depth of 4 cm.
Topics & Concepts
XantheneChemistryPhotoacoustic imaging in biomedicinePhotochemistryCombinatorial chemistryOpticsPhysicsPhotoacoustic and Ultrasonic ImagingNanoplatforms for cancer theranosticsThermography and Photoacoustic Techniques