The Regulation and Characterization of Mitochondrial‐Derived Methylmalonic Acid in Mitochondrial Dysfunction and Oxidative Stress: From Basic Research to Clinical Practice
Yige Liu, Shanjie Wang, Xiaoyuan Zhang, Hengxuan Cai, Jinxin Liu, Shaohong Fang, Bo Yu
Abstract
Methylmalonic acid (MMA) can act as a diagnosis of hereditary methylmalonic acidemia and assess the status of vitamin B12. Moreover, as a new potential biomarker, it has been widely reported to be associated with the progression and prognosis of chronic diseases such as cardiovascular events, renal insufficiency, cognitive impairment, and cancer. MMA accumulation may cause oxidative stress and impair mitochondrial function, disrupt cellular energy metabolism, and trigger cell death. This review primarily focuses on the mechanisms and epidemiology or progression in the clinical study on MMA.
Topics & Concepts
Methylmalonic acidMethylmalonic acidemiaOxidative stressVitamin B12MedicineMitochondrionMethylmalonic aciduriaBiomarkerBioinformaticsInternal medicineBiologyBiochemistryMetabolism and Genetic DisordersMitochondrial Function and PathologyFolate and B Vitamins Research