The vital use of isocyanide-based multicomponent reactions (MCR) in chemical synthesis
Reagan L. Mohlala, E. Mabel Coyanis
Abstract
Abstract Multicomponent (MCRs) reactions are classified as one-pot reaction where more than two starting materials are employed to form a single product that contains the building blocks of the starting components. MCRs are considered a convenient approach in synthetic chemistry and have many advantages over the traditional one or two-component reaction, by reducing the number of sequential multiple steps required and often producing better yields. This chapter dissects the use of isocyanide-based MCRs and the elegant chemistry that they offer to build useful scaffolds in the chemical synthetic field. In addition MCRs are considered as one of the recognisable options for increasing “greenness” during the synthesis of pharmaceutical and industrial products.