Cervicovaginal DNA Virome Alterations Are Associated with Genital Inflammation and Microbiota Composition
Emily A. Kaelin, Peter T. Skidmore, Paweł Łaniewski, LaRinda A. Holland, Dana M. Chase, Melissa M. Herbst‐Kralovetz, Efrem S. Lim
Abstract
HPV infection is an established risk factor for cervical cancer. However, more broadly, the role of the cervicovaginal virome in cervical cancer progression is not well understood. Here, we identified cervicovaginal DNA virome alterations associated with local microenvironment factors (vaginal microbiota and genital inflammation) that influence HPV persistence and progression to cervical cancer. These findings indicate that the cervicovaginal virome plays an important role in women's health.
Topics & Concepts
Human viromeSex organCervical cancerInflammationBiologyMicrobiomeImmunologyCancerMedicineGeneticsGeneGenomeCervical Cancer and HPV ResearchReproductive tract infections researchViral Infections and Vectors