Absolutely “off–on” fluorescent CD-based nanotheranostics for tumor intracellular real-time imaging and pH-triggered DOX delivery
Yuman Dong, Pengcheng Du, Peng Liu
Abstract
-(CDs)-DOX nanotheranostics did not exhibit fluorescence in a normal physiological medium, while strong fluorescence recovery occurred in the tumor intracellular microenvironment due to pH-triggered disintegration, releasing the CDs and DOX. The pH-triggered DOX release and absolute "off-on" fluorescence make the proposed nanotheranostics promising for tumor-specific pH-triggered DOX delivery and imaging.
Topics & Concepts
IntracellularQuenching (fluorescence)FluorescenceBiophysicsChemistryPhotochemistryMaterials scienceOpticsBiochemistryBiologyPhysicsNanoplatforms for cancer theranosticsAdvanced biosensing and bioanalysis techniquesNanoparticle-Based Drug Delivery