Long-Term MALT1 Inhibition in Adult Mice Without Severe Systemic Autoimmunity
Annelies Demeyer, Yasmine Driege, Ioannis Skordos, Julie Coudenys, Kelly Lemeire, Dirk Elewaut, Jens Staal, Rudi Beyaert
Abstract
T cells were strongly reduced. Limited formation of tertiary lymphoid structures was detectable in lungs and stomach, which did not affect overall health. Our data illustrate that MALT1 inhibition in prenatal or adult life has a different outcome and that long-term MALT1 inhibition in adulthood is not associated with severe side effects.
Topics & Concepts
AutoimmunityInflammationRegulatorImmunologySystemic inflammationImmunotherapyCancer researchImmune systemMedicineBiologyGeneticsGeneNF-κB Signaling PathwaysImmune Response and InflammationCytokine Signaling Pathways and Interactions