Aberrations in Lipid Expression and Metabolism in Psoriasis
Julia Nowowiejska, Anna Baran, Iwona Flisiak
Abstract
Psoriasis (PSO) is a common skin disease that affects about 1%-3% of the general population. It is a great medical, social and economic burden since PSO is associated with many comorbidities, of which the most common are cardiometabolic disorders. Psoriatic patients suffer more frequently from obesity, dyslipidemia, atherosclerosis, and nonalcoholic fatty liver disease. Research shows that lipid expression and metabolism disorders are present more often in such patients. This review focuses on a variety of aberrations in lipids in the skin, blood, and adipose tissue in psoriatic patients and their multifactorial impact on the pathogenesis of psoriasis.
Topics & Concepts
PsoriasisLipid metabolismMetabolismExpression (computer science)MedicineBiologyBioinformaticsComputational biologyPhysiologyDermatologyInternal medicineComputer scienceProgramming languagePsoriasis: Treatment and PathogenesisRetinoids in leukemia and cellular processesSphingolipid Metabolism and Signaling