Mutant-selective AKT inhibition through lysine targeting and neo-zinc chelation
Gregory B. Craven, Hang Chu, Jessica D. Sun, Jordan D. Carelli, Brittany Coyne, Hao Chen, Ying Chen, Xiaolei Ma, Subhamoy Das, Wayne Kong, Adam D. Zajdlik, Kin S. Yang, Solomon H. Reisberg, Peter A. Thompson, J. Russell Lipford, Jack Taunton
Topics & Concepts
LysineChelationZincChemistryProtein kinase BMutantPI3K/AKT/mTOR pathwayBiochemistryPhosphorylationSignal transductionAmino acidGeneOrganic chemistrySynthesis and Catalytic ReactionsAmino Acid Enzymes and MetabolismBiochemical and Molecular Research