Comprehensive UHPLC–MS screening methods for the analysis of triazolopyrazine precursor and its genotoxic nitroso-derivative in sitagliptin pharmaceutical formulation
Jakub Jireš, Michal Douša, Petr Gibala, Jan Doubský, Daniel Pěček, David Mervart, Anna Kluk, Ardita Veseli, Stanislav Kalášek, Pavel Řezanka
Topics & Concepts
ChemistryChromatographySitagliptinAmmonium formateTriple quadrupole mass spectrometerFormic acidElectrosprayBioanalysisMass spectrometrySitagliptin PhosphateSelected reaction monitoringAnalytical Chemistry (journal)Tandem mass spectrometryEndocrinologyMedicineMetforminDiabetes mellitusSynthesis and Biological EvaluationChemical Synthesis and AnalysisAnalytical Chemistry and Chromatography