Bcl-xL inhibits tBid and Bax <i>via</i> distinct mechanisms
Fabronia Murad, Ana J. García‐Sáez
Abstract
multiple mechanisms. Altogether, our findings support a model in which the Bcl-2 network not only modulates protein/protein interactions among the family members, but also their respective intracellular localization dynamics, to regulate apoptosis.
Topics & Concepts
CytosolCell biologyMitochondrionBcl-xLBcl-2 familyApoptosisPhosphorylationIntracellularBiologyChemistryProgrammed cell deathBiochemistryEnzymeCell death mechanisms and regulationMitochondrial Function and PathologyATP Synthase and ATPases Research