Apolipoprotein E4 impairs the response of neurodegenerative retinal microglia and prevents neuronal loss in glaucoma
Milica A. Margeta, Zhuoran Yin, Charlotte Madore, Kristen Pitts, Sophia M. Letcher, Jing Tang, Shuhong Jiang, Christian Gauthier, Sebastian R. Silveira, Caitlin M. Schroeder, Eleonora M. Lad, Alan D. Proia, Rudolph E. Tanzi, David M. Holtzman, Susanne Krasemann, Dong Feng Chen, Oleg Butovsky
Topics & Concepts
MicrogliaNeurodegenerationRetinal ganglion cellApolipoprotein EBiologyRetinal degenerationDownregulation and upregulationGlaucomaRetinalAlzheimer's diseaseNeuroscienceRetinaImmunologyMedicinePathologyGeneticsDiseaseInflammationGeneBiochemistryRetinal Diseases and TreatmentsNeuroinflammation and Neurodegeneration MechanismsProtease and Inhibitor Mechanisms