Identifying New Ligands for JNK3 by Fluorescence Thermal Shift Assays and Native Mass Spectrometry
Chongyun Cheng, Miaomiao Liu, Xiaoqin Gao, Dong Wu, Mengchen Pu, Jun Ma, Ronald J. Quinn, Zhi‐Cheng Xiao, Zhijie Liu
Abstract
-1,2,3-triazole-4-carboxamide as a novel and selective JNK3 binder.
Topics & Concepts
SerineMass spectrometryChemistryKinaseScaffoldThreonineFluorescenceDocking (animal)Binding siteComputational biologyBiophysicsBiochemistryCombinatorial chemistryBiologyPhosphorylationMedicineChromatographyPhysicsBiomedical engineeringQuantum mechanicsNursingMelanoma and MAPK PathwaysComputational Drug Discovery MethodsMicrobial Natural Products and Biosynthesis