Novel use of dupilumab in pemphigus vulgaris and pemphigus foliaceus
Christina Jiang, Susuana Adjei, Sueheidi Santiago, Jun Lu, Miguel A. Duran, Stephen K. Tyring
Abstract
Pemphigus vulgaris (PV) and pemphigus foliaceus (PF) belong to a family of autoimmune dermatoses of mucous and/or cutaneous membranes in which acantholysis leads to bullae and erosion formation.1,2 The pathogenesis of PV and PF involve the antibodies against desmogleins, transmembrane glycoproteins associated with desmosomes that mediate cell–cell adhesion within the epidermis.1,2 Antibodies against desmogleins 1/3 are involved in PV, and only antibodies against desmoglein 1 are involved in PF, which contribute to differences in clinical presentation.
Topics & Concepts
Pemphigus foliaceusDupilumabMedicinePemphigus vulgarisDermatologyPemphigusAtopic dermatitisImmunologyAntibodyAutoantibodyAutoimmune Bullous Skin DiseasesCoagulation, Bradykinin, Polyphosphates, and AngioedemaPlatelet Disorders and Treatments