A review on exploring the health benefits and antioxidant properties of bioactive polyphenols
Pushpendra Kumar Jain, Ashish Kumar Parashar, Vivek Shrivastava
Abstract
Polyphenols are a diverse and widely distributed group of plant-derived phytochemicals known for their broad spectrum of biological activities. Found abundantly in fruits, vegetables, grains, tea, coffee, and wine, these compounds are increasingly recognized for their significant contribution to human health. Their benefits are largely attributed to potent antioxidant, anti-inflammatory, and bioactive properties, which support the prevention and management of chronic diseases. Among their many functions, polyphenols serve as powerful antioxidants, capable of neutralizing reactive oxygen species (ROS) and reducing oxidative stress a key contributor to the development of degenerative diseases such as cancer, cardiovascular conditions, and neurodegenerative disorders including Alzheimer’s and Parkinson’s disease. This review explores the classification of polyphenols based on their chemical structures, their major dietary sources, and their bioavailability and metabolism, which influence their biological efficacy. In addition to their antioxidant potential, polyphenols exhibit a wide range of therapeutic activities, including anti-inflammatory, anti-cancer, cardioprotective, and neuroprotective effects. The review also discusses current challenges in optimizing the health benefits of polyphenols, including limited bioavailability, interactions with other dietary components, and variability in individual metabolism. Finally, future research directions are proposed, emphasizing advanced delivery systems, functional food applications, and integrated clinical studies using tools such as metabolomics and nutrigenomics.