Cardiometabolic risk factors are associated with immune cell mitochondrial respiration in humans
Theodore M. DeConne, Eric R. Muñoz, Faria Sanjana, Joshua C. Hobson, Christopher R. Martens
Abstract
Independent of other cardiometabolic risk factors, low-density lipoprotein cholesterol, and systolic blood pressure were found to be negatively associated with several parameters of mitochondrial respiration in peripheral blood mononuclear cells of healthy adults. These data suggest that low-density lipoprotein cholesterol and systolic blood pressure may induce metabolic reprogramming of immune cells, contributing to increased cardiovascular disease risk and impaired immune health.
Topics & Concepts
Blood pressureImmune systemPeripheral blood mononuclear cellInternal medicineCholesterolEndocrinologyRespirationBiologyMedicinePhysiologyImmunologyBiochemistryIn vitroBotanyAdipose Tissue and MetabolismTryptophan and brain disordersAdipokines, Inflammation, and Metabolic Diseases