Role of Chromosome- and/or Plasmid-Located <i>bla</i> <sub>NDM</sub> on the Carbapenem Resistance and the Gene Stability in Escherichia coli
Noriko Sakamoto, Yukihiro Akeda, Yo Sugawara, Yuki Matsumoto, Daisuke Motooka, Tetsuya Iida, Shigeyuki Hamada
Abstract
Carbapenem-resistant Enterobacterales (CRE) carrying bla NDM have spread worldwide since they were first reported in 2009. Many studies using whole-genome sequencing have identified the genetic structures, plasmid scaffolds of bla NDM , and mechanisms of spread via horizontal transfer.
Topics & Concepts
PlasmidBiologyMutantGeneticsGeneChromosomeEscherichia coliImipenemCarbapenemMicrobiologyCircular bacterial chromosomeAntibiotic resistanceBacteriaAntibioticsAntibiotic Resistance in BacteriaInfections and bacterial resistancePharmaceutical and Antibiotic Environmental Impacts