Unraveling the Gene Regulatory Networks of the Global Regulators VeA and LaeA in Aspergillus nidulans
Heungyun Moon, Mi-Kyung Lee, Ilhan Bok, Jin Woo Bok, Nancy P. Keller, Jae‐Hyuk Yu
Abstract
Fungal development and metabolism are genetically programmed events involving specialized cellular differentiation, cellular communication, and temporal and spatial regulation of gene expression. In genus Aspergillus , the global regulators VeA and LaeA govern developmental and metabolic processes by affecting the expression of downstream genes, including multiple transcription factors and signaling elements.
Topics & Concepts
Aspergillus nidulansBiologyGeneSecondary metabolismGeneticsRegulator geneRegulation of gene expressionGene regulatory networkComputational biologyGene expressionMutantBiosynthesisFungal and yeast genetics researchFungal Biology and ApplicationsMicrobial Natural Products and Biosynthesis